There are many reasons behind the problem of desktop icons not responding to mouse clicks. This is a very frustrating situation when you are doing some important work on the computer and suddenly you can't click anything on it. But no need to worry because if you are dealing with the same issue then here you can get some easy steps to fix this issue.
You have to close and restart your window explorer
Check your all keys are working properly of your computer
Sometime running software are also the reason for this problem